Reference
Cards
Lab
Differential Review
| Total Bilirubin | (index) |
|
(visible jaundice > 2.5-3.0 mg/dl, total bilirubin = direct +
indirect fractions): Normal Range: 0.2-1.5 mg/dI or 3-25 umol/l (SI) Increased Total Bilirubin: Liver Biliary Tract Pathology (hepatitis, biliary obstruction [CBD stone, gallstone, stricture, atresia, cancer, surgical trauma, pancreatitis, metastases], cholestasis, cancer [primary, metastases], cirrhosis, sclerosing cholangitis), CHF 
hepatic congestion, sepsis, TPN, meds (halothane, oral contraceptives,
allopurinol, antibiotics, steroids, INH, indocin, methyldopa, sulfonamides,
tolbutamide, chloramphenicol, chlorpromazine), infectious mononucleosis,
liver failure, hereditary pathology (Gilbert's )Increased Direct Bilirubin (conjugated, water soluble, present in urine when elevated), > 0.3 mg/dl or 4 umol/l (SI): biliary obstruction (gallstone, CBD stone, pancreatitis, stricture, cancer [primary - hepatoma, pancreatic, ampullary, cholangiocarcinoma; metastases]), hepatitis (viral, drug, toxic), sepsis, TPN, biliary cirrhosis, alcoholic induced cirrhosis, Dubin Johnson syndrome, Rotor syndrome, Wilson's disease Increased Indirect Bilirubin (unconjugated), > 1.0 mg/dl or 18 umol/l (SI): hemolysis, transfusion reaction, sickle cell anemia, hematoma reabsorption, hepatitis, cirrhosis, sepsis, CHF, cancer, liver failure, Gilbert's disease, Crigler-Najjar |
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