Pathology > Study Images > Male Genitals > Penis > Benign Conditions
Objectives Anat & Hist Congenital Infectious Benign Malignant

IV. Benign Conditions


After completing this section you will be able to:

  • describe the clinical features of Peyronie’s disease and priapism
  • state relevant associations and complication

  1. Peyronie's Disease (Penile Fibromatosis)

This is a disease of unknown cause characterized by focal, fibrous induration of the shaft of the penis associated with abnormal curvature and painful erection. It is associated with Dupuytren's contracture (palmar fibromatosis), which is present in about 25% of cases.

Histologically, dense fibro-collagenous tissue is present in the tunica albuginea or between the tunica and the penile fascia.

The lesion usually recurs after surgical removal.

  1. Priapism

This refers to unwanted, inappropriate (unrelated to sexual activity), persistent, painful erection. Priapism is distinguished from normal erection by absence of tumescence of the glans. It may be idiopathic, associated with sickle cell disease, chronic granulocytic leukemia, spinal cord injury, or secondary to injection of vasodilator agents (e.g. PGE1) into the penis, drugs (e.g. trazadone), thrombosis of the penile veins or to adrenergic-mediated mechanism for detumescence. In priapism of sickle cell disease, the corpora cavernosa are usually engorged and the glans and corpus spongiosum are spared. In a minority however, tricorporal priapism occurs. Priapism, especially tricorporal, may eventuate in impotence.

Objectives Anat & Hist Congenital Infectious Benign Malignant