Pathology > Basic Hematology > Normal Hematopoiesis > Erythrocyte Review > Energy Metabolism

Energy Metabolism

Erythrocyte metabolism is unique in that the mature erythrocyte contains no mitochondria and therefore no Kreb's cycle! Instead the energy needs of the RBC are met largely (95%) by anaerobic glycolysis in the


The shunt supplies the remainder.


*net gain of ATP to maintain osmotic stability

methemoglobin reduction (Fe Hgb-Fe Hgb)

2,3-DPG to modulate Hgb oxygen affinity

NADPH synthesis and glutathione reductase to protect sulfhydryl groups in erythrocyte membranes and hemoglobin

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