Erythrocyte metabolism is unique in that the
mature erythrocyte contains no mitochondria and therefore
no Kreb's cycle! Instead the energy needs of the RBC are met
largely (95%) by anaerobic glycolysis in the
The shunt supplies the remainder.
*net gain of ATP to maintain osmotic
methemoglobin reduction (Fe Hgb-Fe Hgb)
2,3-DPG to modulate Hgb oxygen affinity
NADPH synthesis and glutathione reductase
to protect sulfhydryl groups in erythrocyte membranes
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