The Red Cell Disorders unit is organized mechanistically or physiologically into three major sections: 1) Increased RBC Destruction, 2) Decreased RBC Production, and 3) Blood Loss.
The Increased RBC Destruction or Hemolytic anemia section includes anemias secondary to membrane disorders, enzyme deficiencies, abnormalities of hemoglobin synthesis, antibody mediated destruction, and mechanical trauma.
The Decreased RBC Production section includes anemias secondary to decreased hemoglobin synthesis as in the microcytic anemias of iron deficiency and thalessemia, and the abnormalities of DNA synthesis as in the megaloblastic anemias, abnormalities of proliferation, and failure of differentiation.
The final section is on anemia secondary to Blood loss. Certain proliferative disorders of red cells are considered in the unit on proliferative disorders of white cells.