Normal platelets in the blood stream have a discoid shape
and have little or no interaction with other platelets or
Endothelial damage, specifically exposure of underlying
collagen as shown at left, triggers platelet adhesion.
First, von Willebrand's factor(vWF) binds to subendothelial
collagen. This results in conformational changes in vWF
allowing vWF to bind to the GP Ib receptor on platelets.
Exposure of the basement membrane and release of tissue
factor from damaged endothelialcells serves to activate