Pediatric Radiology > Musculoskeletal > Constitutional Disorders of Bone > Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI) is a group of hereditary disorders of type I collagen synthesis characterized by extremely fragile bones with a propensity to fracture. Often patients will present with multiple fractures at various stages of healing, which can be confused with non-accidental trauma. The underlying osteopenia and the fact that OI fractures tend to involve the diaphysis rather than the metaphyseal corners can help to distinguish the two entities.
Two major types:
Radiographic characteristics of OI:
Osteogenesis Imperfecta Tarda in a 15-year-old male. Lateral radiograph of the right knee demonstrates marked cortical thinning with undertubulation of the long bones (gracile bones).
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