Pediatric Radiology > Neurological > Developmental Abnormalities >Holoprosencephaly
The lack of cleavage of the brain into two hemispheres is called holoprosencephaly. There is a close embryologic association with facial anomalies, and the severity of the brain abnormality is reflected in the severity of the midline facial abnormality. The abnormality is subdivided into alobar, semilobar, and lobar holoprosencephaly.
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