Pediatric Radiology > Neurological > Developmental Abnormalities > Abnormal Nueronal Migration > Lissencephaly


Lissencephaly

Lissencephaly is the arrest of neuronal migration causing either developmental failure of sulci and gyri (agyria) or development of abnormal broad and flat gyri with abnormal shallow sulci (pachygyria). Lesions typically do not appear in isolation. Polymicrogyria is a similar disorder that results in small, disorganized gyri. It is unknown whether this is due to abnormal neuronal migration or cortical dysplasia.

 
Agyria
 
Pachygyria
 
Polymicrogyria in the bilateral parietal lobes.
 


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