Radiobiology > Deterministic Effects > Whole Body Irradiation Syndromes > Hematopoietic Syndrome


Whole Body Irradiation: The Hematopoietic Syndrome

The Bone Marrow Syndrome (Hematopoietic Syndrome)

  • Associated with exposures of at least 3 Gy (300 rad)
  • Mechanism: loss of pluripotent stem cells from hematopoietic tissues
  • Si/Sx: Pancytopenia, leading to infection and hemorrhage
  • Has a latency period 2-4 weeks
  • Rx: Blood products, bone marrow transplant, and antibiotics
  • Survival: 50% spontaneous recovery at exposure of 3.5 Gy. 180 days required to regain maximum function.
  • Few survive doses greater than 6-7 Gy (at doses above 8 Gy, >90% long-term immunosuppression is observed). Death is 1-2 months post-exposure from infection; anemia is not a cause of death
 



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