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Electives - Pathology

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Neuropathology

Elective Number: 2305

Rotation Supervisor: Dr. Maria-Beatriz S. Lopes, msl2e@virginia.edu

Evaluation should be given to: Dr. Lopes

Duration: Maximum 4 weeks, Minimum 2 weeks

Available: Rotations 1-4, 6-12, 13a & 14 (Class of 2019)

A pager is required but will not be provided.

Report to: Dr. Lopes

Time to Report: 8:00 am

Place to Report: HEP 3rd floor, room 3060

Typical day: 8:00 am - 5:00 pm

Attendance: Attendance at elective activities is mandatory.

  • Anyone who is ill or has a personal or family emergency must contact Student Affairs and the Attending on Service.
  • Students are allowed to take off up to 1 day per week to interview between November 1 and February 1.
    • Specific days missed must be approved by the Attending on Service.

Number of students per rotation:

Course Description: Students participate in the conferences and in the diagnostic service of the Division of Neuropathology, which includes the examination of brain smears, frozen sections and permanent sections of neurosurgical specimens and the gross and microscopic examination of brains obtained from the autopsy material in the Department.

Students essentially function as residents in studying at first hand the neuropathological material under the guidance and supervision of a faculty member, and participate in the regular weekly microscopic conference in which current neuropathological material and consultation case material submitted from outside centers are reviewed and discussed.

Additional projects in clinicopathologic correlation and/or experimental neuropathology may be possible during this rotation by pre-arrangement.

Learning Objectives:

  1. To be familiar with the fundamental principles of neuropathologic surgical specimens examination and diagnosis
  2. To perform adequate gross examination of surgical neuropathologic specimens
  3. To know the major classes of primary CNS tumors recognized by the current WHO classification scheme
  4. To know and apply current WHO grading criteria for gliomas
  5. To understand and explain the rationale for 1p/19q, IDH-1, MGMT, and EGFR testing in gliomas
  6. To know and apply current WHO grading criteria for meningiomas
  7. To describe the differential diagnosis for a ring-enhancing mass in the brain (include at least six different entities)
  8. To recognize the main lesions involving the pituitary and sellar region
  9. To understand the complete histological and immunohistochemical workup of a pituitary adenoma
  10. To describe the histological features of normal skeletal muscle and nerve
  11. To distinguish myopathic features from neuropathic features on a skeletal muscle biopsy
  12. To describe the anatomical and histological features of normal eye
  13. To review the basics of neuroanatomy to be able to accompany a brain cutting session
  14. To perform a gross examination of the brain and spinal cord
  15. To describe the major gross neuropathological findings in common disorders
  16. To recognize the major histological characteristics of various brain regions and cord
  17. To recognize the major histopathological processes in common neurologic disorders in an autopsy brain including hypoxia-ischemia, infarcts and hemorrhages, Alzheimer’s disease